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Lymphoscintigraphic and morphometric study of synovial membrane in the osteo-arthritic knee
De colaboração com os Drs. J. Lima, A. Cardoso e os Profs. Doutores R. Branco e N. Canha -
(EUROPEAN JOURNAL OF LYMPHOLOGY AND RELATED PROBLEMS 5 ; 29-33 , 1991).
The present work reports the study of 53 synovial membranes using histology and morphometry. The synovial membrane was collected in the ostheoarthritic knee which presented lymphos-cintigraphic abnormalities. The morphometric study showed inflammatory infiltrate, congestive vessels and fibrosis. Articular lymphoscintigraphy with 99mTc-labeled dextran, demonstated that at 24 hours the tracer disappeared more slowly from the abnormal joint but accumulated more intensely in regional lymph nodes on the diseased side. Statistical analysis of the morphometric and lymphoscintigraphic data shows a significant correlation between lymphatic dysfunction and the synovial membrane fibrosis. There is no significant correlation between other morphometric data (vessels and inflammatory infiltrate) and articular lymphoscintigraphic results.